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[The clinical evaluation of quinine for the treatment of Plasmodium falciparum malaria].
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 1997 May-Jun; Vol. 30 (3), pp. 211-3. - Publication Year :
- 1997
-
Abstract
- Quinine was the first antimalarial drug to be employed and also the first resistance was noticed to. After 1960 quinine urged to be reintroduced in routine therapy alone or in combination. Aiming at evaluating the effectiveness of different schedules we studied 484 patients seen at the Malaria Laboratory. We used quinine alone in 126 patients, quinine plus sulfadoxine and pyrimethamine in 119 patients and quinine plus tetracycline in 239 patients. The results shown that 81% of all patients were treated with success and only 0.6% were R2. and there is no R3. We emphasize a high resistance rate to quinine either alone (23.1%) or associated to sulfadoxine and pyrimethamine (37.8%). A higher resistance rate seen with the combination might be linked to the smaller dose of quinine used in that instance. It is worth noting the high cure rate with the quinine-tetracycline association.
- Subjects :
- Adult
Antimalarials antagonists & inhibitors
Drug Evaluation
Drug Resistance
Drug Therapy, Combination
Humans
Pyrimethamine administration & dosage
Quinine antagonists & inhibitors
Remission Induction
Sulfadoxine administration & dosage
Tetracycline administration & dosage
Time Factors
Antimalarials administration & dosage
Malaria, Falciparum drug therapy
Quinine administration & dosage
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 0037-8682
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 9273567
- Full Text :
- https://doi.org/10.1590/s0037-86821997000300007