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Developmental toxicity of dermally applied crude oils in rats.
- Source :
-
Journal of toxicology and environmental health [J Toxicol Environ Health] 1997 Sep; Vol. 52 (1), pp. 79-93. - Publication Year :
- 1997
-
Abstract
- Two crude oils, differing in viscosity (V) and nitrogen (N) and sulfur (S) content, were evaluated for pre- and postnatal developmental toxicity. In Crude I (low V, low N, low S) studies, the material was applied neat to the clipped backs of pregnant rats at dose levels of 0, 125, 500, 1000 (postnatal only), and 2000 (prenatal only) mg/kg. In Crude II (high V, high N, moderate S) studies, the oil was applied similarly but at dose levels of 0, 30, 125, and 500 mg/kg. Rats were exposed to the crude oils on gestation days (GD) 0-19; application sites were not covered. "Prenatal" rats were killed on GD 20. "Postnatal" rats were allowed to deliver naturally; surviving dams and litters were killed 3-4 wk postpartum. Both crude oils produced maternal and developmental toxicity. Adverse fetal effects included increased in utero death, decreased body weight, and reduced ossification of skeletal elements. Parturition was delayed in Crude II dams at 500 mg/kg. The 4-d viability index was decreased in all Crude II-exposed groups. Pup body weights were decreased by each oil, but at the high dose only. Prenatal effects are probably related to polynuclear aromatic compounds (PAC) found in petroleum. The cause(s) of delayed parturition and postnatal toxicity have not been determined.
- Subjects :
- Abnormalities, Drug-Induced
Administration, Cutaneous
Animals
Animals, Newborn
Body Weight drug effects
Bone Development drug effects
Dermatitis, Irritant pathology
Female
Gestational Age
Male
Pregnancy
Rats
Skin drug effects
Skin pathology
Survival Rate
Embryonic and Fetal Development drug effects
Fetus drug effects
Petroleum toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0098-4108
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of toxicology and environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 9269324
- Full Text :
- https://doi.org/10.1080/00984109708984054