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Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1997 Aug 18; Vol. 237 (2), pp. 359-61. - Publication Year :
- 1997
-
Abstract
- Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/beta-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.
- Subjects :
- Animals
In Vitro Techniques
Ion Channels
Islets of Langerhans metabolism
Male
RNA, Messenger genetics
Rats
Rats, Zucker
Troglitazone
Uncoupling Protein 2
Up-Regulation drug effects
Chromans pharmacology
Hypoglycemic Agents pharmacology
Islets of Langerhans drug effects
Membrane Transport Proteins
Mitochondrial Proteins
Obesity genetics
Proteins genetics
RNA, Messenger biosynthesis
Thiazoles pharmacology
Thiazolidinediones
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 237
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 9268716
- Full Text :
- https://doi.org/10.1006/bbrc.1997.7140