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Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.
- Source :
-
The Journal of general virology [J Gen Virol] 1997 Aug; Vol. 78 ( Pt 8), pp. 1913-8. - Publication Year :
- 1997
-
Abstract
- Immunological correlates of AIDS-free survival after human immunodeficiency virus type 1 (HIV-1) infection are largely unknown. Cytotoxic T lymphocyte (CTL) responses are generally believed to be a major component of protective immunity against viral infections. However, the relationship between HIV-1-specific CTL responses and disease progression rate is presently unclear. Here we show in twelve HIV-1-infected individuals that detection of Rev-specific CTL precursors (CTLp) early in the asymptomatic stage, as well as detection of Rev- and Tat-specific CTLp later during follow-up, inversely correlate with rapid disease progression. No such correlation was found for detection of CTLp against Gag, RT or Nef. Further studies are required to determine whether a protective mechanism is indeed the basis of the observed correlation. The data presented are in agreement with the hypothesis that CTL against proteins that are important for early viral transcription and translation are of particular importance in protection from rapid disease progression.
- Subjects :
- Acquired Immunodeficiency Syndrome immunology
Alleles
Amino Acid Sequence
CD4 Lymphocyte Count
DNA Primers
Disease Progression
Follow-Up Studies
Gene Products, rev chemistry
HIV Seropositivity immunology
HLA-A Antigens genetics
HLA-A1 Antigen genetics
HLA-A1 Antigen immunology
HLA-A2 Antigen genetics
HLA-A2 Antigen immunology
HLA-B8 Antigen genetics
Histocompatibility Testing
Humans
Polymerase Chain Reaction
Time Factors
rev Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
Acquired Immunodeficiency Syndrome physiopathology
Gene Products, rev immunology
Gene Products, tat immunology
HIV Seropositivity physiopathology
HIV-1 immunology
HLA-A Antigens immunology
HLA-B8 Antigen immunology
T-Lymphocytes, Cytotoxic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1317
- Volume :
- 78 ( Pt 8)
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 9266987
- Full Text :
- https://doi.org/10.1099/0022-1317-78-8-1913