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Keeping calcium in its place: Ca(2+)-ATPase and phospholamban.
- Source :
-
Current opinion in structural biology [Curr Opin Struct Biol] 1997 Aug; Vol. 7 (4), pp. 550-6. - Publication Year :
- 1997
-
Abstract
- Electron microscopy is gradually revealing more and more about the structure of the calcium pump from the sarcoplasmic reticulum, Ca(2+)-ATPase. The most recent result reveals the ATP-binding site, and two different avenues are being pursued towards achieving a higher resolution structure. Although no such structures are currently available for phospholamban, various spectroscopies and site-directed mutagenesis have been combined to produce a compelling structural model for its regulation of Ca(2+)-ATPase.
Details
- Language :
- English
- ISSN :
- 0959-440X
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 9266178
- Full Text :
- https://doi.org/10.1016/s0959-440x(97)80121-2