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Prognostic significance of the expressions of metallothionein, glutathione-S-transferase-pi, and P-glycoprotein in curatively resected gastric cancer.
- Source :
-
Oncology [Oncology] 1997 Sep-Oct; Vol. 54 (5), pp. 391-9. - Publication Year :
- 1997
-
Abstract
- Although experimental studies indicate that overexpression of metallothionein (MT), glutathione-S-transferase-pi (GST-pi), or P-glycoprotein (P-GP) is related to the drug resistance of cancer cells, the clinical significance of the overexpression remains to be elucidated. The expressions of MT, GST-pi, and P-GP wre evaluated immunohistochemically in 74 specimens of gastric adenocarcinoma in T1-3N1-2 stages which were resected with curative intent. Fluorinated pyrimidines, mitomycin C, and Adriamycin were prescribed in 73, 54, and 2 patients, respectively. The staining characteristics were investigated in relation to the clinical results. The cell-proliferative activity was studied with anti-proliferating cell nuclear antigen antibody. Expressions of GST-pi and P-GP correlated with the staining intensity of normal mucosa. Five-year disease-free survival rates (DFSRs) of GST-pi-negative and GST-pi-positive groups were 75.0 and 49.0%. The 5-year DFSRs of P-GP-negative and P-GP-positive groups were 68.2 and 38.6%. Concurrent expression among the three proteins was associated with the survival: 5-year DFSR of no- or one-protein-positive group was 75.0%, while those of 2- and 3-protein-positive groups were 56.0 and 38.9%, respectively. Tumors concurrently expressing 2 or 3 proteins have a high proliferative activity. Expressions of MT, GST-pi, and P-GP by the tumor are associated with a poorer prognosis of the patients.
- Subjects :
- Adenocarcinoma mortality
Adenocarcinoma pathology
Aged
Disease-Free Survival
Female
Gastric Mucosa metabolism
Humans
Male
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Prognosis
Stomach Neoplasms mortality
Stomach Neoplasms pathology
Survival Analysis
ATP Binding Cassette Transporter, Subfamily B, Member 1 analysis
Adenocarcinoma chemistry
Gene Expression Regulation, Neoplastic
Glutathione Transferase analysis
Metallothionein analysis
Proliferating Cell Nuclear Antigen analysis
Stomach Neoplasms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0030-2414
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 9260601
- Full Text :
- https://doi.org/10.1159/000227725