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Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 1997 Jul; Vol. 431 (1), pp. 31-6. - Publication Year :
- 1997
-
Abstract
- The endocrine cells in intraductal papillary-mucinous neoplasms (IPN) of the pancreas have rarely been investigated. In the normal pancreatic ducts of normal pancreases (n = 5) there were a few endocrine cells: argyrophil in 5 (100%), chromogranin A in (100%), pancreatic polypeptide (PP) in 3 (60%), and insulin in 7 (20%). These endocrine cells were scattered, and located in the basal portions of pancreatic ducts. In IPN of the pancreas (n = 9), there were many endocrine cells: argyrophil in 7 (78%), argentaffin in 8 (89%), chromogranin A in 8 (89%), PP in 7 (78%), serotonin in 7 (78%), insulin in 4 (44%), and gastrin in 5 (56%). In invasive ductal adenocarcinoma of the pancreas (n = 6), many endocrine cells were also detected: argyrophil cells in (67%), chromogranin A in 3 (50%), insulin in 3 (50%), glucagon in 4 (67%), and somatostatin in 3 (50%). In positive cases, endocrine cells were situated under or among the neoplastic cells and the proportion of endocrine cells in IPN was less than 5% of the total neoplastic cell population. These data show that normal pancreatic ducts contain endocrine cells and that IPN frequently contain argyrophil, argentaffin, chromogranin A, and hormone-containing endocrine cells. These data also suggest that endocrine differentiation occurs during neoplastic transformation and progression of IPN of the pancreas.
- Subjects :
- Adenocarcinoma, Mucinous chemistry
Adenoma chemistry
Aged
Aged, 80 and over
Carcinoma, Ductal, Breast chemistry
Carcinoma, Intraductal, Noninfiltrating chemistry
Chromogranin A
Chromogranins analysis
Chromogranins immunology
Enterochromaffin Cells chemistry
Enterochromaffin Cells pathology
Female
Gastrins analysis
Gastrins immunology
Glucagon analysis
Glucagon immunology
Histocytochemistry
Humans
Immunohistochemistry
Insulin analysis
Insulin immunology
Male
Middle Aged
Pancreatic Neoplasms chemistry
Pancreatic Polypeptide analysis
Pancreatic Polypeptide immunology
Serotonin analysis
Serotonin immunology
Vasoactive Intestinal Peptide analysis
Vasoactive Intestinal Peptide immunology
Adenocarcinoma, Mucinous pathology
Adenoma pathology
Carcinoma, Ductal, Breast pathology
Carcinoma, Intraductal, Noninfiltrating pathology
Pancreatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0945-6317
- Volume :
- 431
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 9247630
- Full Text :
- https://doi.org/10.1007/s004280050066