Back to Search
Start Over
L-deprenyl potentiates cAMP-induced elevation of FGF-2 mRNA levels in rat cortical astrocytes.
- Source :
-
Neuroreport [Neuroreport] 1997 Jul 07; Vol. 8 (9-10), pp. 2165-8. - Publication Year :
- 1997
-
Abstract
- The expression of fibroblast growth factor-2 (FGF-2, basic FGF) is up-regulated in astroglial cells by different stimuli, including glucocorticoid hormones and agents that cause an increase in cyclic AMP (cAMP) levels. In the present study we showed that L-deprenyl, a drug able to rescue neurons from potentially lethal damage, can potentiate FGF-2 induction by 8Br-cAMP in cultured astrocytes. This effect appears to be independent from its well known inhibitory activity on monoamine oxidase (MAO) type B. As astrocyte activation is an important step in response to neuronal injury, our data suggest that potentiation of neurotrophic factor expression may exert neuroprotection and therefore limit the progression of neuronal damage in several pathological situations.
- Subjects :
- Animals
Astrocytes drug effects
Cells, Cultured
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Fibroblast Growth Factor 2 drug effects
Gene Expression drug effects
Nerve Growth Factors drug effects
Pargyline pharmacology
RNA, Messenger drug effects
RNA, Messenger metabolism
Rats
Astrocytes metabolism
Cyclic AMP pharmacology
Fibroblast Growth Factor 2 metabolism
Nerve Growth Factors metabolism
Selegiline pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 8
- Issue :
- 9-10
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 9243604
- Full Text :
- https://doi.org/10.1097/00001756-199707070-00014