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Human T-cell leukemia viruses: epidemiology, biology, and pathogenesis.
- Source :
-
Blood reviews [Blood Rev] 1997 Jun; Vol. 11 (2), pp. 91-104. - Publication Year :
- 1997
-
Abstract
- The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate T-cell leukemia/lymphoma viruses. Initially identified in 1980, the human T-cell lymphotropic virus type I has been implicated as the etiologic agent of adult T-cell leukemia/lymphoma and of a degenerative neurologic disorder known as tropical spastic paraparesis or human T-cell lymphotropic virus type I-associated myelopathy. The intriguing link between human T-cell lymphotropic virus type, T-cell malignancy, and a totally unrelated and non-overlapping neurological disorder suggests divergent and unique pathogenetic mechanisms. This review will address the epidemiology, molecular biology, and pathogenesis of human T-cell leukemia viruses.
- Subjects :
- Adult
Animals
Gene Products, rex metabolism
Gene Products, tax metabolism
HTLV-I Infections genetics
HTLV-I Infections transmission
HTLV-II Infections genetics
HTLV-II Infections transmission
Human T-lymphotropic virus 1 genetics
Human T-lymphotropic virus 2 genetics
Humans
HTLV-I Infections epidemiology
HTLV-II Infections epidemiology
Human T-lymphotropic virus 1 pathogenicity
Human T-lymphotropic virus 2 pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 0268-960X
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Blood reviews
- Publication Type :
- Academic Journal
- Accession number :
- 9242992
- Full Text :
- https://doi.org/10.1016/s0268-960x(97)90015-1