Morphological reactions in the subcutaneous fat after lymphotropic administration of isoniazid: experimental study.

Two experiments were conducted on 36 guinea-pigs. One of them examined the morphology of the distribution of the intravital stain trypan black with isoniazid 1, 3, 6, 24, and 48 hours after their administration into the subcutaneous fat of the neck and axilla. It demonstrated that the agents came from the subcutaneous fat largely to the intrathoracic lymph nodes and lungs via the lymphatics in a retrograde way. The other experiment on 16 healthy guinea-pigs indicated that 1, 2, and 3 months after lymphotropic administration (into the pretrachea and axilla), an infiltrate appeared and increased at the site of drug administration, which became larger after 3 months of lymphotropic injection, and after discontinuation it is completely resolved and the tissue structures of the subcutaneous fat recovered.