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[Intracranial chordomas; histochemical and immunohistochemical examinations].
- Source :
-
Neurologia i neurochirurgia polska [Neurol Neurochir Pol] 1997 Jan-Feb; Vol. 31 (1), pp. 89-101. - Publication Year :
- 1997
-
Abstract
- Chordoma is one of rare intracranial neoplasms (0.2-0.5%). Apart from classic chordoma in 1973 r. Heffelfinger and al. separated chondroid chordoma which showed better prognosis. We studied 4 classic and 3 chondroid intracranial chordomas. All tumours contained chondroitine sulfate and keratan sulfate and showed positive immunohistochemical reactions to cytokeratin, S-100 protein and vimentin, supporting the concept of common origin of both types of chordomas. Immunohistochemical studies of PCNA and Ki-67 antigen and staining AgNOR's did not show significant differences in the proliferative activity between both types chordomas what attests to biological malignancy.
- Subjects :
- Adult
Chondroitin Sulfates analysis
Female
Humans
Immunohistochemistry
Keratan Sulfate analysis
Keratins analysis
Ki-67 Antigen analysis
Male
Middle Aged
Proliferating Cell Nuclear Antigen analysis
S100 Proteins analysis
Vimentin analysis
Biomarkers, Tumor analysis
Brain Neoplasms pathology
Chordoma parasitology
Subjects
Details
- Language :
- Polish
- ISSN :
- 0028-3843
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurologia i neurochirurgia polska
- Publication Type :
- Academic Journal
- Accession number :
- 9235522