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Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.
- Source :
-
Nuclear medicine and biology [Nucl Med Biol] 1997 Apr; Vol. 24 (3), pp. 255-61. - Publication Year :
- 1997
-
Abstract
- A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.
- Subjects :
- Animals
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal pharmacokinetics
Half-Life
Humans
Injections, Intravenous
Injections, Spinal
Iodine Radioisotopes
Mice
Neoplasm Transplantation
Radiation Dosage
Radionuclide Imaging
Radiopharmaceuticals administration & dosage
Radiopharmaceuticals pharmacokinetics
Tissue Distribution
Transplantation, Heterologous
Antibodies, Monoclonal chemistry
Astatine pharmacokinetics
Glioma diagnostic imaging
Radiopharmaceuticals chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0969-8051
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nuclear medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 9228660
- Full Text :
- https://doi.org/10.1016/s0969-8051(97)00060-7