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Actions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1997 Jun 25; Vol. 329 (2-3), pp. 133-6. - Publication Year :
- 1997
-
Abstract
- In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 329
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9226405
- Full Text :
- https://doi.org/10.1016/s0014-2999(97)00185-4