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Nicotinamide attenuates methamphetamine-induced striatal dopamine depletion in rats.
- Source :
-
Neuroreport [Neuroreport] 1997 May 27; Vol. 8 (8), pp. 1883-5. - Publication Year :
- 1997
-
Abstract
- The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of 51% and 23%, respectively, in striatal DA and adenosine 5'-triphosphate (ATP) levels 5 days later. Nicotinamide (500 mg/kg, i.p.) treatment prior to each MA injection attenuated the reductions of striatal DA and ATP contents. Nicotinamide had no long-term effects on striatal DA and ATP levels. These findings suggest that energy impairment might play a role in MA-induced DAergic neurotoxicity in the striatum.
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Dopamine Uptake Inhibitors pharmacology
Energy Metabolism drug effects
Male
Methamphetamine pharmacology
Neostriatum drug effects
Rats
Rats, Sprague-Dawley
Dopamine metabolism
Dopamine Uptake Inhibitors antagonists & inhibitors
Methamphetamine antagonists & inhibitors
Neostriatum metabolism
Niacinamide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 9223070
- Full Text :
- https://doi.org/10.1097/00001756-199705260-00018