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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.
- Source :
-
Cell [Cell] 1997 Jun 27; Vol. 89 (7), pp. 1011-9. - Publication Year :
- 1997
-
Abstract
- Signals from cytokine and antigen receptors play crucial roles during lymphocyte development. Mice lacking interleukin-7 receptor are lymphopenic, due to a defect in cell expansion at an early stage of differentiation, and the few mature T cells that develop in IL-7R-/- animals are functionally impaired. Both defects were rescued completely by overexpression of the anti-apoptosis protein Bcl-2. T cell progenitors lacking antigen receptor molecules are also blocked in differentiation and die, presumably because they fail to receive a positive signal via their pre-T cell receptor. Surprisingly, Bcl-2 did not promote survival or differentiation of T cells in rag-1-/- mice. These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2.
- Subjects :
- Animals
Antigens pharmacology
Antigens, CD metabolism
Apoptosis immunology
CD4-Positive T-Lymphocytes cytology
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes cytology
CD8-Positive T-Lymphocytes immunology
Cell Differentiation drug effects
Cell Differentiation genetics
Cell Differentiation immunology
Cells, Cultured
Gene Expression immunology
Genes, RAG-1 genetics
Humans
Interleukin-7 deficiency
Interleukin-7 genetics
Lymph Nodes cytology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitogens pharmacology
Mutagenesis immunology
Receptors, Interleukin metabolism
Receptors, Interleukin-7
Signal Transduction immunology
Spleen cytology
Stem Cells chemistry
Stem Cells immunology
Thymus Gland cytology
Transgenes immunology
Antigens, CD genetics
CD4-Positive T-Lymphocytes chemistry
CD8-Positive T-Lymphocytes chemistry
DNA-Binding Proteins genetics
Homeodomain Proteins
Proto-Oncogene Proteins c-bcl-2 genetics
Receptors, Interleukin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0092-8674
- Volume :
- 89
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 9215624
- Full Text :
- https://doi.org/10.1016/s0092-8674(00)80289-5