High-performance liquid chromatographic determination of quinine in rat biological fluids.

Authors :: Chmurzyński L
Source :: Journal of chromatography. B, Biomedical sciences and applications [J Chromatogr B Biomed Sci Appl] 1997 Jun 06; Vol. 693 (2), pp. 423-9.
Publication Year :: 1997
Abstract: A high-performance liquid chromatographic (HPLC) method with ultraviolet detection for the determination of quinine in rat biological fluids is described. Due to its selectivity and sensitivity, the proposed method can be used in the case of such rat biological fluids as cerebrospinal fluid (CSF) and perilymph for which the accessible volumes are limited to 100 microl and 10 microl, respectively. Consequently, the assay method has been applied to the measurements of quinine concentration in rat plasma, CSF and perilymph samples.

Subjects :: Animals
Antimalarials blood
Antimalarials cerebrospinal fluid
Chromatography, High Pressure Liquid
Perilymph chemistry
Quinine blood
Quinine cerebrospinal fluid
Rats
Sensitivity and Specificity
Antimalarials analysis
Quinine analysis

Language :: English
ISSN :: 1387-2273
Volume :: 693
Issue :: 2
Database :: MEDLINE
Journal :: Journal of chromatography. B, Biomedical sciences and applications
Publication Type :: Academic Journal
Accession number :: 9210448
Full Text :: https://doi.org/10.1016/s0378-4347(97)00074-1

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