Back to Search
Start Over
Inhibition of dipeptidyl peptidase IV (CD26) by peptide boronic acid dipeptides.
- Source :
-
Journal of enzyme inhibition [J Enzyme Inhib] 1997 Jan; Vol. 11 (3), pp. 151-69. - Publication Year :
- 1997
-
Abstract
- Peptide boronic acid dipeptide compounds were analyzed for their ability to inhibit recombinant human dipeptidylpeptidase IV (CD26, DPPIV). Rate constants for the peptide boronates are difficult to obtain because the active boronic acid dipeptide exists in equilibrium with a cyclic inactive species in aqueous solution. Rate constants were determined for the inhibition of DPPIV using several peptide boronates at different pH values. Val-boroPro forms the most tightly bound complex with DPPIV; the first order half life for dissociation of the inactive enzyme-inhibitor complex at 23 degrees C is approximately 27 days.
Details
- Language :
- English
- ISSN :
- 8755-5093
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition
- Publication Type :
- Academic Journal
- Accession number :
- 9204385
- Full Text :
- https://doi.org/10.3109/14756369709027647