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Simple high-performance liquid chromatographic method for the determination of acyclovir in human plasma using fluorescence detection.
- Source :
-
Journal of chromatography. B, Biomedical sciences and applications [J Chromatogr B Biomed Sci Appl] 1997 May 23; Vol. 693 (1), pp. 241-4. - Publication Year :
- 1997
-
Abstract
- A simple high-performance liquid chromatographic method using fluorescence detection was developed for the determination of acyclovir in human plasma. The method entailed direct injection of the plasma sample after deproteination. It is both specific and sensitive with a detection limit of 30 ng/ml at a signal-to-noise ratio of 3:1, and is thus suitable for use in pharmacokinetic studies of acyclovir. The method had a mean absolute recovery of 96%, while the within-day and between-day coefficients of variation and percentages error were all less than 8%. The calibration curve was linear over a concentration range of 62.5-4000 ng/ml.
Details
- Language :
- English
- ISSN :
- 1387-2273
- Volume :
- 693
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. B, Biomedical sciences and applications
- Publication Type :
- Academic Journal
- Accession number :
- 9200543
- Full Text :
- https://doi.org/10.1016/s0378-4347(97)00041-8