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Apolipoprotein E polymorphism has no independent effect on plasma levels of lipoprotein(a).
- Source :
-
Atherosclerosis [Atherosclerosis] 1997 Jun; Vol. 131 (2), pp. 243-8. - Publication Year :
- 1997
-
Abstract
- Previous studies show conflicting results concerning an influence of apolipoprotein E (apo E) phenotype on lipoprotein(a) (Lp(a)) plasma levels. We speculated that it is not the apo E phenotype itself but rather its effect on plasma lipid concentrations that might influence Lp(a) levels. In 1562 subjects concentrations of triglycerides, LDL-cholesterol and Lp(a) were measured by standard laboratory methods. Apo(a) and apo E isoforms were determined by sodium dodecyl sulfate gel electrophoresis and isoelectric focusing, respectively, followed by immunoblotting. An univariate analysis revealed a significant influence of apo(a) isoforms, apo E phenotype, triglycerides and LDL-cholesterol on Lp(a) plasma levels (ANOVA: P < 0.001, P < 0.02, P < 0.001 and P < 0.001, respectively). In a multivariate analysis, however, the influence of the apo E phenotype was no longer significant (P>0.10), whereas apo(a) isoforms, LDL-cholesterol quintiles and triglyceride quintiles explained 29.2, 2.8 and 1.0% of the variation of the Lp(a) levels (for all three variables: P < 0.001). We conclude that apo E polymorphism does not exert an independent effect on Lp(a) concentrations. Any influence is mediated through the effect of apo E polymorphism on plasma lipids.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Apolipoproteins E blood
Child
Child, Preschool
Cholesterol, LDL blood
Female
Humans
Hyperlipidemias blood
Hyperlipidemias genetics
Immunoblotting
Male
Middle Aged
Phenotype
Retrospective Studies
Triglycerides blood
Apolipoproteins E genetics
Lipoprotein(a) blood
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 131
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 9199278
- Full Text :
- https://doi.org/10.1016/s0021-9150(97)06105-4