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Randomized placebo-controlled trial of teicoplanin in the antibiotic prophylaxis of infection following manipulation of burn wounds.
- Source :
-
The British journal of surgery [Br J Surg] 1997 Jun; Vol. 84 (6), pp. 848-53. - Publication Year :
- 1997
-
Abstract
- Background: Burn wound surgery or change of dressings commonly causes bacteraemia. The use of antibiotic prophylaxis has not been tested adequately in a controlled trial.<br />Methods: A randomized double-blind placebo-controlled study was performed to determine the effect on Gram-positive bacteraemia and clinical outcome of a single dose of teicoplanin (12 mg/kg intravenously) given at burns surgery or change of dressings.<br />Results: A total of 134 patients were entered into the study, representing 220 episodes of dressing or debridement (110 episodes in each group). There was a significant difference between the groups with respect to perioperative Gram-positive bacteraemia: eight episodes (7 per cent) in the teicoplanin group versus 51 (46 per cent) in the placebo group (P < 0.001). However, good clinical outcome was similar in both groups (80 of 110 versus 77 of 110 respectively, P = 0.7). Only eleven patients had bacteraemia caused by Gram-negative species alone. Bacteriological response in terms of wound culture showed no significant difference between the groups: 63 (57 per cent) of 110 episodes versus 58 (53 per cent) of 110 respectively respectively.<br />Conclusion: Prevention of Gram-positive bacteraemia did not affect postoperative recovery.
- Subjects :
- Adult
Anti-Bacterial Agents adverse effects
Bacteremia prevention & control
Burns microbiology
Double-Blind Method
Drug Resistance, Microbial
Female
Humans
Male
Middle Aged
Teicoplanin adverse effects
Anti-Bacterial Agents therapeutic use
Antibiotic Prophylaxis adverse effects
Bacterial Infections prevention & control
Burns surgery
Teicoplanin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1323
- Volume :
- 84
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The British journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 9189106