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Prevalence of elevated anticardiolipin antibodies in pregnant women with unexplained elevations of alpha-fetoprotein.
- Source :
-
Journal of reproductive immunology [J Reprod Immunol] 1997 Apr; Vol. 33 (1), pp. 71-81. - Publication Year :
- 1997
-
Abstract
- The goal was to determine what proportion of pregnant women with unexplained elevations of maternal serum alpha-fetoprotein (MSAFP) have increased levels of anticardiolipin antibodies (ACA), and if this might explain the increased prevalence of adverse pregnancy outcomes. Maternal serum alpha-fetoprotein levels of 12,295 pregnant women were evaluated at 15-19.5 gestational weeks. Elevated readings (> 2.5 MOM) were identified in 190 women (1.5%) and 86 (0.7%) of these had unexplained causes. Specimens (80) were recovered and ACA levels for cardiolipin were determined using enzyme-linked immunosorbant assay. Positive IgG ACA were identified in 10 out of 80 cases (12.5%) of elevated MSAFP; 3 out of 80 cases (3.8%) had positive IgM ACA. The control women with normal MSAFP levels had positive IgG ACA in 3 of 86 cases (3.5%) and 1 of 86 cases (1.2%) for IgM. Women with increased MSAFP and positive ACA had infants with an average birth weight of 2684 +/- 889 g compared to 2793 +/- 847 g in women with increased MSAFP and normal ACA. No significant differences in IgG ACA were found in pregnant women with unexplained elevated MSAFP (10/80, 12.5%) compared to women with normal MSAFP (3/86, 3.5%). As expected, lower birth weight was identified in women who had elevated MSAFP (2738 +/- 868 g) vs. women with normal MSAFP 3181 +/- 1082 g (P = 0.004), independent of ACA positivity.
- Subjects :
- Adolescent
Adult
Demography
Female
Fetal Death blood
Fetal Death epidemiology
Fetal Death immunology
Fetal Growth Retardation blood
Fetal Growth Retardation epidemiology
Fetal Growth Retardation immunology
Humans
Obstetric Labor, Premature blood
Obstetric Labor, Premature epidemiology
Obstetric Labor, Premature immunology
Pregnancy
Prevalence
Antibodies, Anticardiolipin blood
Pregnancy Outcome epidemiology
alpha-Fetoproteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0165-0378
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of reproductive immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9185078
- Full Text :
- https://doi.org/10.1016/s0165-0378(97)01014-0