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Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.
- Source :
-
American journal of medical genetics [Am J Med Genet] 1997 May 31; Vol. 74 (3), pp. 254-62. - Publication Year :
- 1997
-
Abstract
- An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (approximately 68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P < 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an approximately 9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.
- Subjects :
- Alleles
Chromosome Mapping
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 9
Female
Genome, Human
Genotype
Humans
Male
National Institute of Mental Health (U.S.)
Nuclear Family
Pedigree
United States
Bipolar Disorder genetics
Genetic Linkage
Genetic Markers
Subjects
Details
- Language :
- English
- ISSN :
- 0148-7299
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 9184307
- Full Text :
- https://doi.org/10.1002/(sici)1096-8628(19970531)74:3<254::aid-ajmg4>3.0.co;2-q