Telomerase in hepatocellular carcinogenesis.

Despite the recent advances in diagnostic techniques of HCC, diagnosis of HCC is still difficult and ambiguous when HCC is small and of the well differentiated type. The results presented here demonstrated that strong telomerase activity was frequently detected in HCC irrespective of the stage or size of the nodules but neither in non-tumor diseased liver nor in normal liver. Telomerase activity determination can be a useful additional tool for the diagnosis of early well-differentiated HCC.