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Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model.
- Source :
-
Atherosclerosis [Atherosclerosis] 1997 May; Vol. 131 (1), pp. 25-33. - Publication Year :
- 1997
-
Abstract
- To study the influence of dietary fatty acids on arterial thrombosis tendency 65 groups of male rats were fed diets containing 50% of their digestible energy as fat from 32 different oils and fats. After 8 weeks their arterial thrombosis tendency was assessed by measuring the obstruction time (OT) of a loop-shaped polythene cannula inserted into the abdominal aorta. Using multiple regression analysis log10 OT was modelled as a function of the relative amounts of the various dietary fatty acids and their combinations. The best fit (R2 = 0.79) was obtained for the sums of all monoenoic and (n-6) and (n-3) polyenoic fatty acids, which appeared antithrombotic. The fit for the sum of all saturated fatty acids, which had a prothrombotic effect, was almost as good (R2 = 0.76). The ratio between dietary polyunsaturated and saturated fatty acids (P:S ratio) appeared a strong predictor of arterial thrombosis tendency (R2 = 0.77). Marine oils did not have a more powerful antithrombotic effect than could be expected on the basis of their P:S ratios. Using stepwise regression analysis myristic acid, 14:0, was shown to be the strongest prothrombotic fatty acid whereas linoleic acid, 18:2(n-6), was the strongest antithrombotic fatty acid. Since the number of marine oils was very limited the effects of the 'fish fatty acids' eicosapentaenoic acid, 20:5(n-3) and docosahexaenoic acid, 22:6(n-3), on arterial thrombus formation could not be tested reliably. The same appeared true for gamma-linolenic acid, 18:3(n-6), and stearidonic acid, 18:4(n-3), present in a few vegetable oils only.
- Subjects :
- Animals
Dietary Fats, Unsaturated administration & dosage
Energy Intake
Fatty Acids administration & dosage
Fatty Acids, Unsaturated administration & dosage
Fish Oils administration & dosage
Linoleic Acid
Linoleic Acids administration & dosage
Male
Myristic Acid
Myristic Acids administration & dosage
Rats
Rats, Wistar
Regression Analysis
Arterial Occlusive Diseases etiology
Dietary Fats administration & dosage
Disease Models, Animal
Thrombosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 131
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 9180241
- Full Text :
- https://doi.org/10.1016/s0021-9150(97)06094-2