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Direct vascular effects of plantain extract in rats.
- Source :
-
Experimental physiology [Exp Physiol] 1997 May; Vol. 82 (3), pp. 501-6. - Publication Year :
- 1997
-
Abstract
- Responses of the aorta and portal veins isolated from rats to aqueous extract of plantain (Musa paradisiaca) were studied. The extract produced concentration-dependent relaxation in both noradrenaline- and KCl-contracted aortic rings. The maximum relaxation in noradrenaline-contracted rings was 52.49 +/- 6.63% and in KCl-contracted rings was 77.51 +/- 2.52% of the initial tensions developed in response to the contractile agents. The extract also produced significant (P < 0.01) inhibition of the maximum aortic contractile response to noradrenaline and completely abolished the spontaneous contractions of the portal veins. Serotonin (5-hydroxytryptamine), unlike the extract, produced contraction rather than relaxation of the aortic rings. The results show a non-specific relaxing and inhibiting effect of plantain extract on aortic and portal smooth muscles, an effect that is not attributable to its abundant serotonin content.
Details
- Language :
- English
- ISSN :
- 0958-0670
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Experimental physiology
- Publication Type :
- Academic Journal
- Accession number :
- 9179569
- Full Text :
- https://doi.org/10.1113/expphysiol.1997.sp004042