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Dynamic distribution of basic fibroblast growth factor during epulis formation: an immunohistochemical study in an enhanced healing process of the gingiva.
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 1997 May; Vol. 26 (5), pp. 224-32. - Publication Year :
- 1997
-
Abstract
- Basic fibroblast growth factor (bFGF) is thought to play an important role in wound healing. However, its histological localization, both in normal and pathological conditions in the oral mucosa, has not been well documented. We have studied the immunolocalization of bFGF in normal gingiva and gingival epulis specimens corresponding to different organizing stages. In normal gingiva, bFGF was detected in subpopulations of macrophages, mast cells and most endothelial cells in the lamina propria. Granulation tissue in epulides was histopathologically classified into six organizing stages. In stages 1 and 2, a small number of bFGF-positive macrophages was seen at the periphery of ulcer bases. In stages 3 and 4, histologically characterized by prominent capillary proliferation, large numbers of bFGF-positive macrophages and mast cells were located within granulation tissue. A positive reaction for bFGF was also found in some endothelial cells and in myxoedematous stroma that was rich in heparan sulfate proteoglycan. In stages 5 and 6, when fibrosis was accelerated, bFGF-positive macrophages and mast cells decreased in number and were localized only at the periphery of the fibrous tissue. These findings suggest that maximum amounts of bFGF are synthesized and released from some macrophages and mast cells into the extracellular matrix during neovascularization of granulation tissue.
- Subjects :
- Endothelium, Vascular chemistry
Fibroblast Growth Factor 2 analysis
Fibroblasts chemistry
Gingiva chemistry
Gingival Diseases physiopathology
Granulation Tissue blood supply
Granuloma, Pyogenic physiopathology
Humans
Immunohistochemistry
Macrophages chemistry
Mast Cells chemistry
Neovascularization, Physiologic
Fibroblast Growth Factor 2 physiology
Gingival Diseases pathology
Granulation Tissue chemistry
Granuloma, Pyogenic pathology
Wound Healing physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0904-2512
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 9178174
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1997.tb01228.x