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Features of the cytokines secreted by adult T cell leukemia (ATL) cells.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 1996 May; Vol. 21 (5-6), pp. 443-7. - Publication Year :
- 1996
-
Abstract
- Adult T cell leukemia (ATL) cells show a mature helper-inducer T cell phenotype and are thought to secrete many kinds of cytokines in vivo, complicating the clinical features in these patients. In an attempt to specify the cytokines produced by ATL cells, we measured the cytokine concentration in the culture supernatants of three ATL cell lines, all of which were confirmed to be true peripheral blood ATL cell in origin. All these cell lines showed the same cytokine production profile, secreting IL1-alpha, IL1-beta, LD78(MIP-l alpha), TNF-alpha, IFN-gamma, and GM-CSF, but not secreting IL-1 alpha, IL-1 beta, IL-1 receptor antagonist (IL-1 Ra), IL-4, IFN-alpha, and G-CSF irrespective of the stimulatory agents used. Such limited cytokine production may indicate the specific origin of ATL cells within the helper-inducer T cell subtypes. Moreover, these results explain some of the unusual clinical features of ATL patients.
- Subjects :
- Adult
Chemokine CCL4
Culture Media, Conditioned chemistry
Granulocyte Colony-Stimulating Factor metabolism
Humans
Interferon-gamma metabolism
Interleukin-8 metabolism
Interleukins metabolism
Macrophage Inflammatory Proteins metabolism
Neoplastic Stem Cells drug effects
Th1 Cells drug effects
Tumor Cells, Cultured drug effects
Tumor Cells, Cultured metabolism
Tumor Necrosis Factor-alpha metabolism
Cytokines metabolism
Leukemia-Lymphoma, Adult T-Cell physiopathology
Neoplastic Stem Cells metabolism
Th1 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 21
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 9172809
- Full Text :
- https://doi.org/10.3109/10428199609093442