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Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032).
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1997 Apr 28; Vol. 233 (3), pp. 697-9. - Publication Year :
- 1997
-
Abstract
- The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
- Subjects :
- Amino Acid Sequence
Binding Sites genetics
Humans
In Vitro Techniques
Kinetics
Myeloblastin
Recombinant Proteins genetics
Recombinant Proteins pharmacology
Serine Proteinase Inhibitors genetics
Serpins genetics
Leukocytes enzymology
Serine Endopeptidases metabolism
Serine Proteinase Inhibitors pharmacology
Serpins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 233
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 9168917
- Full Text :
- https://doi.org/10.1006/bbrc.1997.6526