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Predictive value of serum sex hormone binding globulin for the occurrence of hepatocellular carcinoma in male patients with cirrhosis.
- Source :
-
Journal of hepatology [J Hepatol] 1997 Jan; Vol. 26 (1), pp. 96-102. - Publication Year :
- 1997
-
Abstract
- Background/aims: The incidence of hepatocellular carcinoma is higher in males, presumably due to the influence of sex steroids. Therefore, to further assess the role of sex steroids in the occurrence of hepatocellular carcinoma, this study investigated the predictive value of different sex hormones and their binding protein.<br />Methods: Among 101 male patients with cirrhosis included in a prospective screening study, 29 developed hepatocellular carcinoma. We assessed the predictive value of 17 clinico-biological and 4 serum hormonal variables collected at enrollment, by the log-rank test and the Cox model.<br />Results: Age (p = 0.003), bilirubin (p = 0.04), sex-hormone-binding-globulin (p = 0.006) and albumin (p = 0.08) were predictive using the log-rank test, while estradiol and total and free testosterone were not. The Cox model showed age (p = 0.0003; relative risk = 7.52), sex-hormone-binding globulin (p = 0.001, relative risk = 3.37) and albumin (p = 0.02, relative risk = 2.94) as the most predictive parameters.<br />Conclusion: We conclude that high serum sex-hormone-binding-globulin levels have an independent predictive value for the occurrence of hepatocellular carcinoma. Serum sex-hormone-binding-globulin could be used to define patients at high risk for hepatocellular carcinoma and could hypothetically play a role in hepatocarcinogenesis.
- Subjects :
- Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular complications
Carcinoma, Hepatocellular epidemiology
Female
Follow-Up Studies
Humans
Incidence
Liver Cirrhosis blood
Liver Neoplasms blood
Liver Neoplasms complications
Liver Neoplasms epidemiology
Logistic Models
Male
Mass Screening methods
Middle Aged
Predictive Value of Tests
Prospective Studies
Carcinoma, Hepatocellular diagnosis
Liver Cirrhosis complications
Liver Neoplasms diagnosis
Sex Hormone-Binding Globulin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 9148029
- Full Text :
- https://doi.org/10.1016/s0168-8278(97)80015-3