Pharmacokinetics and radiosensitizing effect of PR-350.

Authors :: Hirokawa K
Nakajima T
Tsumura M
Nishita T
Yamada R
Onoyama Y
Source :: Radiation medicine [Radiat Med] 1997 Jan-Feb; Vol. 15 (1), pp. 45-9.
Publication Year :: 1997
Abstract: Purpose: The in vivo pharmacokinetics and sensitizing effects of PR-350, a newly developed, highly water-soluble radiosensitizer were examined.<br />Materials and Methods: C3H/HeJ mice bearing SCC-VII tumor cells were used in the experiments. Results were compared with those of PR-28 and SR-2508.<br />Results: The intratumoral concentration of PR-350 reached the maximum value of 77.7 mg/kg 20 min after intravenous injection. The concentration in the brain was below the detection limit. The enhancement ratios of PR-350 calculated using the growth delay method were 0.9 for PR-350 at 50 mg/kg and 1.4 for PR-350 at 100 mg/kg, compared with 1.4 for SR-2508 at 100 mg/kg and 1.0 for PR-28 at 100 mg/kg.<br />Conclusion: PR-350 and SR-2508 revealed similar sensitizing effects. The side effects of PR-350 are expected to be equal to or less than those of SR-2508. PR-350 seems to be a promising radiosensitizer.