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Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 1997 May 15; Vol. 17 (10), pp. 3392-400. - Publication Year :
- 1997
-
Abstract
- Physiological and pharmacological properties of possible subtypes of the native glycine receptor were investigated in retinal neurons using whole-cell voltage-clamp techniques. Two discrete inhibitory glycine responses were identified in ganglion cells. The responses could be distinguished pharmacologically: one was sensitive to strychnine and the other to 5,7-dichlorokynurenic acid. The two responses had different kinetics: the former had a fast onset and fast desensitization, whereas the latter had a slower onset and was much more sustained. The physiological and pharmacological distinctions suggest that the responses are mediated by different receptors. These receptors transduce glycinergic synaptic signals to ganglion cells, where they serve as low- and high-pass filters, respectively, of EPSPs.
- Subjects :
- Alanine pharmacology
Ambystoma
Animals
Electrophysiology
Excitatory Amino Acid Antagonists pharmacology
Glycine Agents pharmacology
Kynurenic Acid analogs & derivatives
Kynurenic Acid pharmacology
Receptors, Glycine agonists
Receptors, Glycine antagonists & inhibitors
Retinal Ganglion Cells chemistry
Retinal Ganglion Cells drug effects
Serine pharmacology
Strychnine pharmacology
Synaptic Transmission drug effects
Synaptic Transmission physiology
Taurine pharmacology
Glycine pharmacology
Receptors, Glycine analysis
Retinal Ganglion Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0270-6474
- Volume :
- 17
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 9133365