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Gender-specific nonrandom association between the alpha 1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease.
- Source :
-
Genetic epidemiology [Genet Epidemiol] 1997; Vol. 14 (2), pp. 169-80. - Publication Year :
- 1997
-
Abstract
- A common polymorphism in the alpha 1-antichymotrypsin (ACT) gene has been found co modify the APOE*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender- and age-related distributions of these two polymorphisms in two large population-based samples of Caucasians (n = 803) and Nigerian Blacks (n = 730). Significantly higher frequencies of the ACT*A (78.6% vs. 48.4%; P < 0.001) and APOE*4 (25.6% vs. 15.6%; P < 0.001) alleles were observed in Nigerian Blacks than in Caucasians. In Caucasian women but not in men, the frequency of the APOE*4 allele was significantly lower in the ACT/AA genotype as compared to the ACT/AT and ACT/TT genotypes, while a reverse trend was seen for the APOE*3 allele frequency among the ACT genotypes. The distribution of the ACT*A allele between the APOE*4 carriers and non-APOE*4 carriers was also different in Caucasian women but not in men. A similar gender-specific nonrandom association between the two polymorphisms was observed in Black women but this was not as strong as observed in Caucasian women. When the two samples were stratified by age group, an association or trend of association was observed in all age groups in women only. These data indicate the existence of a nonrandom association between the APOE and ACT loci in women which may have an important implication for the higher prevalence of Alzheimer's disease in women.
- Subjects :
- Adult
Aged
Aged, 80 and over
Aging genetics
Black People genetics
Chromosome Mapping
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Nigeria
Risk Factors
Alzheimer Disease genetics
Apolipoproteins E genetics
Polymorphism, Genetic
Sex Characteristics
White People genetics
alpha 1-Antichymotrypsin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0741-0395
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Genetic epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 9129962
- Full Text :
- https://doi.org/10.1002/(SICI)1098-2272(1997)14:2<169::AID-GEPI6>3.0.CO;2-2