Back to Search
Start Over
Inhibition by adrenomedullin of the adrenergic neurogenic response in canine mesenteric arteries.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 1997 Mar; Vol. 73 (3), pp. 259-61. - Publication Year :
- 1997
-
Abstract
- Adrenomedullin (AM) inhibited the pressor action caused by transmural electrical stimulation in perfused isolated canine mesenteric arteries. The inhibitory potency of AM was greater than that of calcitonin gene-related peptide (CGRP) or proadrenomedullin NH2-terminal 20 peptide (PAMP). [8-37]CGRP did not affect the inhibitory action of AM, but suppressed the CGRP-induced inhibition. It may be concluded that AM has an ability to inhibit adrenergic neuronal transmission without the mediation of CGRP1 receptors in the peripheral vasculature, and this inhibition partly participates in the potent hypotensive action of AM.
- Subjects :
- Adrenomedullin
Animals
Calcitonin Gene-Related Peptide pharmacology
Dogs
Electric Stimulation
Female
Hypotension chemically induced
Male
Mesenteric Arteries metabolism
Miotics pharmacology
Muscle Contraction drug effects
Muscle Relaxation drug effects
Peptide Fragments pharmacology
Proteins pharmacology
Mesenteric Arteries drug effects
Muscle, Smooth, Vascular drug effects
Peptides pharmacology
Synaptic Transmission drug effects
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9127823
- Full Text :
- https://doi.org/10.1254/jjp.73.259