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Pathogenicity of Escherichia coli O157:H7 in the intestines of neonatal calves.
- Source :
-
Infection and immunity [Infect Immun] 1997 May; Vol. 65 (5), pp. 1842-8. - Publication Year :
- 1997
-
Abstract
- Cattle are an important reservoir of Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains, foodborne pathogens that cause hemorrhagic colitis and hemolytic uremic syndrome in humans. EHEC O157:H7 strains are not pathogenic in calves >3 weeks old. Our objective was to determine if EHEC O157:H7 strains are pathogenic in neonatal calves. Calves <36 h old inoculated with EHEC O157:H7 developed diarrhea and enterocolitis with attaching and effacing (A/E) lesions in both the large and small intestines by 18 h postinoculation. The severity of diarrhea and inflammation, and also the frequency and extent of A/E lesions, increased by 3 days postinoculation. We conclude that EHEC O157:H7 strains are pathogenic in neonatal calves. The neonatal calf model is relevant for studying the pathogenesis of EHEC O157:H7 infections in cattle. It should also be useful for identifying ways to reduce EHEC O157:H7 infections in cattle and thus reduce the risk of EHEC O157:H7 disease in humans.
- Subjects :
- Animals
Bacterial Adhesion
Cattle
Diarrhea microbiology
Enterocolitis microbiology
Escherichia coli Infections immunology
Germ-Free Life
Ileum microbiology
Ileum pathology
Ileum ultrastructure
Immunohistochemistry
Inflammation microbiology
Intestine, Large microbiology
Intestine, Large pathology
Intestine, Small microbiology
Intestine, Small pathology
Male
Microscopy, Electron
Swine
Escherichia coli Infections microbiology
Escherichia coli O157 pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 65
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 9125570
- Full Text :
- https://doi.org/10.1128/iai.65.5.1842-1848.1997