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Cytotoxicity to isolated rabbit hepatocytes by lymphocytes from children with liver disease.
- Source :
-
The Journal of pediatrics [J Pediatr] 1977 Oct; Vol. 91 (4), pp. 584-9. - Publication Year :
- 1977
-
Abstract
- A test of lymphocyte cytotoxicity for isolated adult rabbit hepatocytes has been performed using lymphocytes from 40 children with acute or chronic liver disease. Positive cytotoxicity was not observed in 26 children without liver disease and rarely in 13 children with disease affecting primarily the biliary tract. Temporarily positive tests were found in those with acute hepatocellular disease, but tests remained positive in patients with chronic active hepatitis, while liver function tests remained abnormal. Persistently positive test occurred in those with liver disease associated with alpha-antitrypsin deficiency. Such altered immunoresponsiveness could be an important pathogenic mechanism leading to chronic liver disease in childhood.
- Subjects :
- Acute Disease
Adolescent
Animals
Biliary Tract Diseases immunology
Child
Child, Preschool
Chronic Disease
Cytotoxicity Tests, Immunologic
Female
Hepatitis immunology
Hepatitis, Viral, Human immunology
Humans
Infant
Liver cytology
Liver Function Tests
Male
Rabbits
Cytotoxicity, Immunologic
Liver immunology
Liver Diseases immunology
Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 91
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 908978
- Full Text :
- https://doi.org/10.1016/s0022-3476(77)80507-6