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Total lymphoid irradiation in rheumatoid arthritis. A ten-year followup.
- Source :
-
Arthritis and rheumatism [Arthritis Rheum] 1997 Mar; Vol. 40 (3), pp. 426-9. - Publication Year :
- 1997
-
Abstract
- Objective: To report the findings of a 10-year followup of patients enrolled in a randomized trial of total lymphoid irradiation (TLI) versus chemotherapy for rheumatoid arthritis (RA).<br />Methods: A retrospective analysis of the charts of 19 patients who had been included in a randomized trial comparing TLI and chemotherapy for the treatment of RA.<br />Results: Ten years after the start of the trial, a higher number of TLI-treated patients had died (7 of 10), compared with patients who had received chemotherapy (2 of 9). In addition, 3 of the TLI-treated patients developed B cell-related malignancies, whereas no such malignancies developed in the control group.<br />Conclusion: TLI was associated with a less-favorable long-term outcome than chemotherapy. These data stress the importance of careful long-term followup in experimental trials of immunosuppressive agents.
- Subjects :
- Aged
CD4 Lymphocyte Count
CD4-CD8 Ratio
Combined Modality Therapy
Drug Therapy, Combination
Follow-Up Studies
Humans
Middle Aged
Randomized Controlled Trials as Topic
Survival Rate
Time Factors
Whole-Body Irradiation mortality
Arthritis, Rheumatoid radiotherapy
Lymphoid Tissue radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0004-3591
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 9082928
- Full Text :
- https://doi.org/10.1002/art.1780400306