Back to Search Start Over

Mouse strain and source of L-tryptophan affects hepatic nuclear tryptophan binding.

Authors :
Sidransky H
Verney E
Source :
Toxicology [Toxicology] 1997 Mar 14; Vol. 118 (1), pp. 37-47.
Publication Year :
1997

Abstract

This study describes that the affinity for specific L-tryptophan binding to hepatic nuclei in vitro is markedly decreased in NZBWF1 mice in comparison to that in Swiss mice. Also, the hepatic nuclei of NZBWF1 mice have a significantly decreased binding response in vitro to Showa Denko L-tryptophan (implicated in the eosinophilia-myalgia syndrome) or to its contaminants, 1,1'-ethylidenebis(tryptophan) or 3-phenylamino-L-alanine, when each is added to control, non-implicated L-tryptophan compared with hepatic nuclei of Swiss mice. Enhanced hepatic protein synthesis induced by tube-feeding control L-tryptophan is much less in NZBWF1 mice than in Swiss mice. Tube-feeding of Showa Denko L-tryptophan induced less stimulation of hepatic protein synthesis than did control L-tryptophan in Swiss mice but essentially none in NZBWF1 mice. NZBWF1 mice have a genetically altered response to L-tryptophan which may prove to be useful is studying the role of L-tryptophan in health and in disease.

Details

Language :
English
ISSN :
0300-483X
Volume :
118
Issue :
1
Database :
MEDLINE
Journal :
Toxicology
Publication Type :
Academic Journal
Accession number :
9074652
Full Text :
https://doi.org/10.1016/s0300-483x(96)03588-3