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Mouse strain and source of L-tryptophan affects hepatic nuclear tryptophan binding.
- Source :
-
Toxicology [Toxicology] 1997 Mar 14; Vol. 118 (1), pp. 37-47. - Publication Year :
- 1997
-
Abstract
- This study describes that the affinity for specific L-tryptophan binding to hepatic nuclei in vitro is markedly decreased in NZBWF1 mice in comparison to that in Swiss mice. Also, the hepatic nuclei of NZBWF1 mice have a significantly decreased binding response in vitro to Showa Denko L-tryptophan (implicated in the eosinophilia-myalgia syndrome) or to its contaminants, 1,1'-ethylidenebis(tryptophan) or 3-phenylamino-L-alanine, when each is added to control, non-implicated L-tryptophan compared with hepatic nuclei of Swiss mice. Enhanced hepatic protein synthesis induced by tube-feeding control L-tryptophan is much less in NZBWF1 mice than in Swiss mice. Tube-feeding of Showa Denko L-tryptophan induced less stimulation of hepatic protein synthesis than did control L-tryptophan in Swiss mice but essentially none in NZBWF1 mice. NZBWF1 mice have a genetically altered response to L-tryptophan which may prove to be useful is studying the role of L-tryptophan in health and in disease.
- Subjects :
- Alanine analogs & derivatives
Alanine pharmacology
Animals
Binding, Competitive
Cell Nucleus metabolism
Liver ultrastructure
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Mice, Inbred NZB
Protein Biosynthesis
Selenic Acid
Selenium Compounds pharmacology
Sodium Selenite pharmacology
Tryptophan analogs & derivatives
Tryptophan chemistry
Liver metabolism
Tryptophan metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-483X
- Volume :
- 118
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 9074652
- Full Text :
- https://doi.org/10.1016/s0300-483x(96)03588-3