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Immunohistochemical study of hepatocellular carcinoma-specific aldehyde dehydrogenase.

Authors :
Shibuya A
Takeuchi A
Shibata H
Saigenji K
Yoshida A
Source :
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement [Alcohol Alcohol Suppl] 1994; Vol. 29 (1), pp. 119-23.
Publication Year :
1994

Abstract

Tumor-associated aldehyde dehydrogenase (ALDH) was reported in cases of human hepatocellular carcinoma and animal hepatoma models. This ALDH isozyme is similar to ALDH3 which exists in the stomach and lung; however, the biochemical and clinical significance of this unique ALDH isozyme have not been established. Human tumor-associated ALDH was purified, and polyclonal antibodies prepared. Using these antibodies, specific development of tumor-associated ALDH was confirmed by immunohistochemical techniques. It was found that about 50% of hepatocellular carcinomas reacted with the antibody. This unique ALDH isozyme may be a novel tumor marker of hepatocellular carcinoma.

Details

Language :
English
ISSN :
1358-6173
Volume :
29
Issue :
1
Database :
MEDLINE
Journal :
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
Publication Type :
Academic Journal
Accession number :
9063810