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[Functional screening of p53 status in tumor cells using Saccharomyces cerevisiae].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1997 Feb; Vol. 24 (4), pp. 466-70. - Publication Year :
- 1997
-
Abstract
- We have detected both germ-line and somatic p53 mutations in lymphocytes, cell lines and tumor tissues using a functional analysis of p53 tumor suppressor gene based on yeast transcription assay. Through our screening projects of the p53 gene, a number of missense p53 mutations were identified as loss-of-function mutations. This method, previously termed FASAY, is rapid, sensitive, less-expensive and can be automated for screening both somatic and germ-line p53 mutations.
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 9063485