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T-2 tetraol is cytotoxic to a chicken macrophage cell line.
- Source :
-
Poultry science [Poult Sci] 1997 Feb; Vol. 76 (2), pp. 311-3. - Publication Year :
- 1997
-
Abstract
- Cytotoxic effects of T-2 tetraol, a T-2 toxin derivative, on the MQ-NCSU chicken macrophage cell line were quantified by direct in vitro exposure. Macrophage cultures were exposed to 1, 10, 20, 40, 80, 160, and 320 micrograms/mL of T-2 tetraol for 1 h. Macrophage viability after exposure to T-2 tetraol. Macrophage viability was reduced by increasing concentrations of T-2 tetraol (linear effect, P < or = 0.001; quadratic effect, P < or = 0.025). The ability of macrophages to adhere to glass surfaces was impaired by increasing concentrations of T-2 tetraol (linear effect, P < or = 0.003). This experiment demonstrates that T-2 tetraol is cytotoxic to chicken macrophages in vitro.
Details
- Language :
- English
- ISSN :
- 0032-5791
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Poultry science
- Publication Type :
- Academic Journal
- Accession number :
- 9057211
- Full Text :
- https://doi.org/10.1093/ps/76.2.311