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Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1997 Mar; Vol. 41 (3), pp. 611-6. - Publication Year :
- 1997
-
Abstract
- From a side-by-side comparative study, the acyclic nucleoside phosphonates (R)-9-(2-phosphonylmethoxypropyl)adenine [(R)-PMPA] and 9-(2-methylidene-3-phosphonomethoxypropyl)guanine (MDL 74,968) proved more selective in their inhibitory effect on human immunodeficiency virus types 1 and 2, feline immunodeficiency virus, and Moloney murine sarcoma virus (MSV) in cell cultures than the 9-(2-phosphonylmethoxyethyl) derivatives of adenine (PMEA) and guanine (PMEG). In particular, PMEG proved quite toxic. PMEA, (R)-PMPA, and MDL 74,968 afforded a marked delay in MSV-induced tumor initiation in MSV-infected newborn NMRI mice and substantially delayed associated animal death at doses as low as 4 to 10 mg/kg of body weight. Treatment of the NMRI mice with PMEA, (R)-PMPA, and MDL 74,968 at 25 or 50 mg/kg resulted in a high percentage of long-term survivors.
- Subjects :
- Adenine analogs & derivatives
Adenine pharmacology
Adenine therapeutic use
Animals
Animals, Newborn
Cell Line
Fibroblasts
Guanine analogs & derivatives
Guanine pharmacology
Guanine therapeutic use
Humans
Mice
Mice, Inbred C3H
Organophosphorus Compounds pharmacology
Organophosphorus Compounds therapeutic use
Retroviridae Infections virology
Tenofovir
Antiviral Agents pharmacology
Antiviral Agents therapeutic use
Organophosphonates
Retroviridae drug effects
Retroviridae Infections drug therapy
Sarcoma Viruses, Murine
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 9056002
- Full Text :
- https://doi.org/10.1128/AAC.41.3.611