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The effect of artemisinin on granulocyte function assessed by flow cytometry.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1997 Jan; Vol. 39 (1), pp. 99-101. - Publication Year :
- 1997
-
Abstract
- The effect of dihydroartemisinin, artemisinin and artesunate (0.1, 0.5, 5 and 50 mg/L) on phagocytic function and release of reactive oxygen products by neutrophils was studied by flow cytometry. Incubation with dihydroartemisinin, artemisinin and artemether resulted in a decreased capacity to phagocytose Escherichia coli (0.1-50 mg/L: 62-40%, 66-32% and 59-47% of the control values, respectively; P < 0.001 for all). Conversely, the derivatives enhanced the intracellular generation of reactive oxygen intermediates (0.1-50 mg/L: 146-140%, 174-197% and 188-136% of the control values, respectively; P < 0.001 for all). Artemisia derivatives enhance the reactive oxygen response of neutrophils but depress their phagocytic ability at therapeutic blood levels.
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 9044035
- Full Text :
- https://doi.org/10.1093/jac/39.1.99