Back to Search Start Over

The effect of artemisinin on granulocyte function assessed by flow cytometry.

Authors :
Wenisch C
Parschalk B
Zedwitz-Liebenstein K
Wernsdorfer W
Graninger W
Source :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1997 Jan; Vol. 39 (1), pp. 99-101.
Publication Year :
1997

Abstract

The effect of dihydroartemisinin, artemisinin and artesunate (0.1, 0.5, 5 and 50 mg/L) on phagocytic function and release of reactive oxygen products by neutrophils was studied by flow cytometry. Incubation with dihydroartemisinin, artemisinin and artemether resulted in a decreased capacity to phagocytose Escherichia coli (0.1-50 mg/L: 62-40%, 66-32% and 59-47% of the control values, respectively; P < 0.001 for all). Conversely, the derivatives enhanced the intracellular generation of reactive oxygen intermediates (0.1-50 mg/L: 146-140%, 174-197% and 188-136% of the control values, respectively; P < 0.001 for all). Artemisia derivatives enhance the reactive oxygen response of neutrophils but depress their phagocytic ability at therapeutic blood levels.

Details

Language :
English
ISSN :
0305-7453
Volume :
39
Issue :
1
Database :
MEDLINE
Journal :
The Journal of antimicrobial chemotherapy
Publication Type :
Academic Journal
Accession number :
9044035
Full Text :
https://doi.org/10.1093/jac/39.1.99