Back to Search
Start Over
Distribution of Fos-immunoreactivity in rat brain following a dipsogenic dose of captopril and effects of angiotensin receptor blockade.
- Source :
-
Brain research [Brain Res] 1997 Jan 30; Vol. 747 (1), pp. 43-51. - Publication Year :
- 1997
-
Abstract
- Immunohistochemical techniques were used to detect Fos in the brain following subcutaneous administration of the angiotensin converting enzyme inhibitors captopril or enalapril at 0.5 mg/kg to conscious rats. Increased Fos-like immunoreactivity was observed in many neurons in the lamina terminalis, and in regions of the hypothalamus. Captopril at this dose also caused water drinking in other rats. Pre-treatment with the angiotensin AT1 receptor antagonist ZD7155 (10 mg/kg) given subcutaneously prevented the captopril-induced increase in Fos in the lamina terminalis. This dose of ZD7155 also prevented captopril-induced drinking in other rats. With a higher dose (50 mg/kg) of captopril or enalapril, there was no increase in Fos in the lamina terminalis. This dose of captopril was not dipsogenic. The results are consistent with the proposal that the lower dose (0.5 mg/kg) of captopril or enalapril increases circulating angiotensin I levels which are then converted to angiotensin II in the organum vasculosum of the lamina terminalis and subfornical organ. Stimulation of neurons at these sites may subserve water drinking and sodium appetite.
- Subjects :
- Angiotensin I metabolism
Angiotensin II metabolism
Animals
Enalapril pharmacology
Hypothalamus cytology
Hypothalamus metabolism
Immunohistochemistry
Male
Naphthyridines pharmacology
Rats
Rats, Sprague-Dawley
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors pharmacology
Brain Chemistry drug effects
Captopril pharmacology
Drinking drug effects
Proto-Oncogene Proteins c-fos biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 747
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 9042526
- Full Text :
- https://doi.org/10.1016/s0006-8993(96)01178-x