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Supplemental dietary chromium does not influence ACTH, cortisol, or immune responses in young calves inoculated with bovine herpesvirus-1.
- Source :
-
Journal of animal science [J Anim Sci] 1997 Jan; Vol. 75 (1), pp. 217-23. - Publication Year :
- 1997
-
Abstract
- Twelve Holstein bull calves (6 to 8 wk of age) were used to determine the influence of supplemental dietary Cr on ACTH, cortisol, and immune responses of calves experimentally inoculated with bovine herpesvirus-1 (BHV-1). Calves supplemented with Cr received 3 mg Cr/d (Chromium, n = 6) of a high-Cr-yeast product. Following 53 d of treatment, all calves were fitted with jugular catheters, and blood samples were collected every 4 h into tubes containing ETDA. Twenty-four hours later, all calves were inoculated intranasally with BHV-1 (1 x 10(7) plaque-forming units in each naris). Serial blood collection continued at 4-h intervals for 6 d. Plasma was harvested, immediately frozen in liquid nitrogen, and stored at -20 degrees C. Individual rectal temperatures and urine samples were collected at the same time each day. Rectal temperatures were elevated (P < .05) on d 2, 3, 4, and 5 but were not affected by Cr treatment. Treatment with Cr did not affect secretion of ACTH, cortisol, or plasma tumor necrosis factor-alpha, although clear circadian variation in ACTH and cortisol occurred. No differences were detected in the concentrations of trace minerals excreted daily in the urine, lymphocyte proliferative response to mitogen stimulation, and neutrophil bactericidal function. The acute phase proteins, ceruloplasmin and fibrinogen, also were not affected by treatment or viral challenge. These data suggest the Cr supplementation using high-Cr yeast (3 mg/d) did not alter stress responses of calves experimentally inoculated with BHV-1.
- Subjects :
- Animals
Body Temperature physiology
Body Weight physiology
Cattle
Cattle Diseases physiopathology
Ceruloplasmin analysis
Chromium administration & dosage
Circadian Rhythm physiology
Dose-Response Relationship, Drug
Fibrinogen analysis
Food, Fortified
Hematocrit
Hemoglobins analysis
Herpesviridae Infections blood
Herpesviridae Infections immunology
Lymphocytes pathology
Male
Neutrophils pathology
Time Factors
Tumor Necrosis Factor-alpha analysis
Zinc urine
Adrenocorticotropic Hormone blood
Antibodies, Viral metabolism
Cattle Diseases blood
Cattle Diseases immunology
Chromium pharmacology
Diet veterinary
Herpesviridae Infections veterinary
Herpesvirus 1, Bovine immunology
Hydrocortisone blood
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8812
- Volume :
- 75
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of animal science
- Publication Type :
- Academic Journal
- Accession number :
- 9027569
- Full Text :
- https://doi.org/10.2527/1997.751217x