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Preoperative radiotherapy for resectable cancer of the middle-distal rectum: its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope.
- Source :
-
International journal of colorectal disease [Int J Colorectal Dis] 1996; Vol. 11 (6), pp. 283-6. - Publication Year :
- 1996
-
Abstract
- 20 patients with rectal cancer within 8 cm of the anal verge were studied. Endoscopic endosonography was carried out before and after pre-operative radiotherapy (45 Gy over three weeks). The local extent (tumour stage and diameter) was compared with the results of histopathological examination of the resected specimen after anterior resection or total rectal excision. The Tumour Regression Grade (TRG) and lymph node status were also estimated. Two patients were not evaluated endosonographically. Two (11%) of the remaining 18 patients showed ultrasound evidence of down staging (14/18 uT3/4 pre-radiotherapy: 12/18 uT3/4 after) and tumour diameter was significantly reduced. Tumour Regression Grade estimation showed evidence of response to treatment, showing regression of more than 50% in 13 (65%) of cases. Involved nodes were less than 5 mm in diameter in 45% of cases. Histopathological evidence of nodal metastatic regression was seen in 13 (28%) of all involved nodes found. The ultrasonically determined response to radiotherapy may offer useful information in predicting outcome and possibly in selecting surgery.
- Subjects :
- Adenocarcinoma diagnostic imaging
Adenocarcinoma pathology
Adenocarcinoma surgery
Adult
Aged
Colonoscopy
Female
Humans
Lymph Nodes pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Preoperative Care
Radiotherapy Dosage
Rectal Neoplasms pathology
Rectal Neoplasms surgery
Adenocarcinoma radiotherapy
Endosonography
Rectal Neoplasms diagnostic imaging
Rectal Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0179-1958
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of colorectal disease
- Publication Type :
- Academic Journal
- Accession number :
- 9007624
- Full Text :
- https://doi.org/10.1007/s003840050063