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[Comparison of serum concentrations of caffeine, 4-methylaminoantipyrine, sulfamethazine and debrisoquin following oral administration of these substances as a cocktail in type II diabetics before and after insulin therapy].
- Source :
-
Die Pharmazie [Pharmazie] 1996 Oct; Vol. 51 (10), pp. 750-3. - Publication Year :
- 1996
-
Abstract
- A cocktail of 4 substances (caffeine/CYP1A/CYP1A2, metamizol/CYP2B, debrisoquin/CYP2D6 and sulfamethazine/N-acetyltransferase) was administered to 15 maturity-onset diabetics before and 6 months after insulin therapy (IT) to examine changes in hepatic biotransformation capacity in humans under pathological conditions. Blood and urine samples were taken 6 h after oral administration of the drugs. There were no differences in acetylation- and hydroxylationsphenotyping before or during IT. However, a significant increase in concentration of free sulfamethazine during IT can be interpreted as induction of N-acetyltransferase by poor metabolic control. Comparison of caffeine-concentration showed no significant differences. Obviously in humans CYP1A2 is not influenced by type-II-diabetes mellitus. Concentration of 4-methyl-antityprine (4-MAA), a metabolite of metamizol, was significantly increased during IT. This results shows a possible induction of CYP2B by poor metabolic control.
- Subjects :
- Adult
Aged
Anti-Infective Agents administration & dosage
Anti-Infective Agents pharmacokinetics
Caffeine administration & dosage
Caffeine pharmacokinetics
Central Nervous System Stimulants administration & dosage
Central Nervous System Stimulants pharmacokinetics
Debrisoquin administration & dosage
Debrisoquin pharmacokinetics
Diabetes Mellitus, Type 2 drug therapy
Dipyrone administration & dosage
Dipyrone analogs & derivatives
Dipyrone pharmacokinetics
Drug Combinations
Female
Humans
Male
Middle Aged
Sulfamethazine administration & dosage
Sulfamethazine pharmacokinetics
Sympatholytics administration & dosage
Sympatholytics pharmacokinetics
Cytochrome P-450 Enzyme System metabolism
Diabetes Mellitus, Type 2 metabolism
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Isoenzymes metabolism
Pyrazolones
Subjects
Details
- Language :
- German
- ISSN :
- 0031-7144
- Volume :
- 51
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 8999440