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PDGF mediates a neuron-astrocyte interaction in the developing retina.
- Source :
-
Neuron [Neuron] 1996 Dec; Vol. 17 (6), pp. 1117-31. - Publication Year :
- 1996
-
Abstract
- Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFR alpha antibody or a soluble extracellular fragment of PDGFR alpha. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell-cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development.
- Subjects :
- Animals
Animals, Newborn growth & development
Astrocytes cytology
COS Cells
Cell Division
Mice
Mice, Transgenic
Nerve Net drug effects
Neurons cytology
Phenotype
Platelet-Derived Growth Factor metabolism
Rats
Receptor, Platelet-Derived Growth Factor alpha
Receptors, Platelet-Derived Growth Factor antagonists & inhibitors
Receptors, Platelet-Derived Growth Factor metabolism
Retinal Vessels physiology
Astrocytes physiology
Cell Communication physiology
Neurons physiology
Platelet-Derived Growth Factor physiology
Retina growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 8982160
- Full Text :
- https://doi.org/10.1016/s0896-6273(00)80244-5