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Fasting insulin level underestimates risk of non-insulin-dependent diabetes mellitus due to confounding by insulin secretion.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 1997 Jan 01; Vol. 145 (1), pp. 18-23. - Publication Year :
- 1997
-
Abstract
- Fasting insulin has been used as a surrogate measure of insulin sensitivity in studies of non-insulin-dependent diabetes mellitus (NIDDM) risk, but the fasting insulin-NIDDM association may be confounded by insulin secretion, which correlates negatively with NIDDM risk and positively with fasting insulin level. In a prospective 5-year study of 137 nondiabetic Japanese-American men in King County, Washington State, higher fasting insulin was not strongly related to NIDDM (odds ratio (OR) = 1.37, 95% confidence interval (CI) 0.80-2.34), but this odds ratio increased substantially after adjustment for insulin secretion (OR = 2.92, 95% CI 1.41-6.06). Research on NIDDM risk in relation to fasting insulin may yield biased effect measures unless adjusted for insulin secretion.
Details
- Language :
- English
- ISSN :
- 0002-9262
- Volume :
- 145
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 8982018
- Full Text :
- https://doi.org/10.1093/oxfordjournals.aje.a009027