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Successful foscarnet therapy for mucocutaneous infection with herpes simplex virus in a recipient after unrelated bone marrow transplantation.

Authors :
Iino T
Gondo H
Ohno Y
Minagawa H
Iwasaki H
Maruyama T
Nakashima H
Niho Y
Source :
Bone marrow transplantation [Bone Marrow Transplant] 1996 Dec; Vol. 18 (6), pp. 1185-8.
Publication Year :
1996

Abstract

A 36-year-old Japanese man who received an unrelated bone marrow transplant (BMT) developed severe mucocutaneous infection with herpes simplex virus (HSV) type 1 during oral acyclovir prophylaxis. The lesions progressed despite treatment with intravenous acyclovir and vidarabine. The HSV isolates were sensitive acyclovir, vidarabine and foscarnet in vitro, but peripheral CD3- or CD19-positive cells were barely detectable even 4 months after transplant. A 12-day course of treatment with foscarnet led to a rapid improvement. Foscarnet therapy should be considered for all severe HSV infections following BMT, regardless of whether or not the HSV isolates are sensitive to acyclovir.

Details

Language :
English
ISSN :
0268-3369
Volume :
18
Issue :
6
Database :
MEDLINE
Journal :
Bone marrow transplantation
Publication Type :
Academic Journal
Accession number :
8971394