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Antiandrogen. IV. C-17 spiro 2-oxasteroids.

Authors :
Koizumi N
Takegawa S
Mieda M
Shibata K
Source :
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1996 Nov; Vol. 44 (11), pp. 2162-4.
Publication Year :
1996

Abstract

The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.

Subjects

Subjects :
Androgen Antagonists pharmacology
Animals
Female
Genitalia, Male drug effects
Magnetic Resonance Spectroscopy
Male
Orchiectomy
Organ Size drug effects
Rats
Rats, Wistar
Steroids pharmacology
Androgen Antagonists chemical synthesis
Steroids chemical synthesis

Details

Language :
English
ISSN :
0009-2363
Volume :
44
Issue :
11
Database :
MEDLINE
Journal :
Chemical & pharmaceutical bulletin
Publication Type :
Academic Journal
Accession number :
8945781
Full Text :
https://doi.org/10.1248/cpb.44.2162
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